Call now for the latest availability and to book!

For discounts and room offers exclusive to World Executive, quote the code below when you call!

Discount Code: 82801

Europe: 00-800-11-20-11-40
US & Canada Call:

Fast Hotel Reservations

Adults Rooms

Hampton Inn & Suites Houston-Medical Center/Astrodome

1715 Old Spanish Trail, Houston, Texas, USA

Hampton Inn & Suites Houston-Medical Center/Astrodome - Houston, USA

Hampton Inn & Suites Houston-Medical Center/Astrodome is located between Texas Medical Center and AstroDomain, 1 mile north of I-610 South. Other area attractions include 6 Flags Astroworld/Waterworld, the biggest entertainment complex in Texas, golf courses, the zoological gardens, museums, sporting events, shopping and designer boutiques, Sam Houston Race Park, and Space Center Houston, 27 miles southeast of the hotel. Within .5 mile you can dine at Luby's Cafeteria, Steak èn Shake, or Subway.
We feature 120 rooms, including two-bedroom suites, Jacuzzi suites, king with micro-fridge, and king office, exercise facility and outdoor pool. Each room is equipped with iron/boards, coffee makers, and hair dryers. We also offer a Suite Shop, a Manager's Reception (Wed. p.m.), and shuttle service to/from the medical center.
Amenities include complimentary continental breakfast bar every morning in our spacious lobby, free local calls, TV with cable, cribs, and refrigerators. Laundry/valet services, guest laundromat, meeting/banquet facilities, and connecting rooms are available for a nominal fee.

Location Description

The hotel is centrally located next to the World-Renowned Texas Medical Center and the Astrodome Arenas.
George Bush Houston Intercontinental Airport 35 MI, N.
William P Hobby Airport 13 MI, S.
Downtown Houston 4 MI, N.
Galleria Shopping Center 7 MI, W.


From George Bush Intercontinental Airport - Take I-45 S to Hwy. 288 S to the Old Spanish Trail exit and go west 2 miles.
From William P Hobby Airport - Take I-45 N to Loop 610 W and exit at Fannin.
Take fork to the right, turn on Old Spanish Trail. Hotel is on the right.
From the Medical Center - Travel south on Fannin for approximately 2 1/2 miles to Old Spanish Trail and turn right.


  • Astrodome Sports/Conv Ctr - 0.5 Miles S.
  • Baylor College of Medicine - 0.5 Miles N.
  • Ben Taub General Hospital - 0.5 Miles N.
  • Cullen Eye Institiute - 0.5 Miles N.
  • Dept Health/Human Services - 0.5 Miles N.
  • Hospice at Texas Med. Ctr. - 0.5 Miles N.
  • M.D. Anderson Cancer Center - 0.5 Miles N.
  • Rice University - 4.0 Miles N.
  • Shriner's Hospitals - 0.5 Miles N.
  • St Luke's Episcopal Hospital - 0.5 Miles N.
  • TX A&M Albert Alkek Inst. - 0.5 Miles N.
  • TX Woman Univ Inst of Health - 0.5 Miles N.
  • Texas A&M University - 0.5 Miles N.
  • Texas Children's Hospital - 0.5 Miles N.

Houston, Texas Hotels and City Guide

Houston Hotels and Houston Guide with Houston maps, top attractions, room reservations and hotel deals at a wide range of the best Houston hotels

Top Destinations

New York 14:34 -8C
Tokyo 03:34 6C
Hong Kong 02:34 16C
Paris 20:34 1C
London 19:34 -0C

Search Destinations & Hotels

Win with World Executive!

Sign up for our newsletter & you could win $20 vouchers!

Follow WorldExecutive on Twitter

Hotels Nearby

Best Western Fountainview Inn & Suites Near Galleria »
Best Western Greenspoint Inn & Suites »
Best Western Northwest Inn & Suites »
Best Western Plaza Hotel & Suites at Medical Center »
Best Western Sam Houston Inn & Suites »
Best Western Westchase Mini-Suites »
Best Western Windsor Suites »
Crown Plaza Houston West »
Holiday Inn Hou SW / Sugar Land / Bltwy8 Hotel »
Holiday Inn Houston Airport Hotel IAH - Texas TX »
Holiday Inn Houston Astrodome Hotel »
Holiday Inn Houston East Channelview Hotel »
Holiday Inn Houston Greenway Hotel - Texas TX »
Holiday Inn Houston Hotel at the Medical Center - Texas TX »
Holiday Inn Houston Hwy Hotel »
Holiday Inn Express Baytown I - 10e @ Garth Rd, TX »
Holiday Inn Express Hotel & Suites Houston FM 1960 (Champion's AR »
Holiday Inn Express Hotel & Suites Houston Med Center/Reliant Pk »
Holiday Inn Express Hotel & Suites Houston-Beltway 8 (Iah West) »
Holiday Inn Express Hotel & Suites Houston-Dwtn Conv Ctr »
Holiday Inn Express Hotel & Suites Houston-Kingwood »
Holiday Inn Express Hotel & Suites Houston-Nw (Brookhollow) »
Holiday Inn Express Hotel & Suites Houston-Nw(Hwy 290 & Fm 1960) »
Holiday Inn Express Hotel & Suites Houston-Westchase Bltwy 8 »
Holiday Inn Express Hotel & Suites Jacinto City - Houston East, TX »
Holiday Inn Express Houston - Hobby Airport, TX »
Holiday Inn Express Houston West Energy Corridor »
Holiday Inn Express Katy, Texas »
Houston Hwy 59s/Hillcroft »
Four Seasons Houston »